Hydrochloric Acid → HCID 19423876, compound

Participants

Reaction Steps

0.56 g of 3-{2-[2-(3-difluoromethoxyphenyl)ethyl]phenoxymethyl}-1-methylpiperidine [prepared as described in step (a) above] was dissolved in 5 ml of dioxane, and 0.45 ml of a 4N solution of hydrogen chloride in dioxane was added to the solution, which was then concentrated by distillation under reduced pressure. The resulting solid was dissolved in a small amount of methanol, and about 50 ml of ethyl acetate were added to the solution, which was then allowed to stand at room temperature for one hour. The crystals which precipitated were collected by filtration and dried in vacuo, to give 0.43 g (yield 70%) of the title compound as colorless crystals, melting at 174°-175° C.

Provenance & Evidence