1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 54052906, compound

Participants

Reaction Steps

Following a procedure similar to that described in the first part of Preparation 3, 2.51 g of 3-(2-benzyloxyphenyl)propanal, 5.6 g of 2-methoxymethoxybenzylphosphonium chloride (prepared as described in Preparation 2) and 1.91 g of 1,8-diazabicyclo[5,4,0]-undec-7-ene were reacted in 50 ml of acetonitrile. The crude product, extracted as described in the first part of Preparation 3, was purified by column chromatography through silica gel, using a 10:1 by volume mixture of hexane and ethyl acetate as the eluent, to give 2.52 g (yield 64%) of 1-(2-methoxymethoxyphenyl)-4-(2-benzyloxyphenyl)-1-butene as a colorless oil.

Provenance & Evidence