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1,8-Diazabicyclo(5.4.0)undec-7-ene → 4-(2-Naphthyl)-1-(2-benzyloxyphenyl)-1-butene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| 反応物 | 3-(2-Naphthyl)propanal | HCID 10176412 | — |
| 反応物 | 2-Benzyloxybenzyltriphenylphosphonium chloride | HCID 19423967 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 4-(2-Naphthyl)-1-(2-benzyloxyphenyl)-1-butene | HCID 53689246 | 82.7% |
反応手順
Following a procedure similar to that described in the first part of Preparation 3, 1.73 g of 3-(2-naphthyl)propanal prepared as described above, 4.65 g of 2-benzyloxybenzyltriphenylphosphonium chloride (prepared as described in Preparation 1) and 2.15 g of 1,8 -diazabicyclo[5,4,0]undec-7-ene were reacted in 200 ml of acetonitrile. The reaction mixture was worked up and purified as described in the first part of Preparation 3, to obtain 2.83 g (yield 82%) of 4-(2-naphthyl)-1-(2-benzyloxyphenyl)-1-butene as a colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05556864 |
| 出典データセット | uspto-grants-1996_09 |
| ORD ID | ord-9c69bc0188464b8fa60decc38c779dc2 |
| 出典メモ | uspto-grants-1996_09 |