反应详情

A solution of 3.00 g of 3-chlorobenzaldehyde and 6.49 g of (triphenylphosphoranylidene)acetaldehyde in 100 ml of acetonitrile was heated under reflux for 5 hours. At the end of this time, the reaction mixture was concentrated by evaporation under reduced pressure, and the resulting residue was purified by column chromatography through silica gel, using a 4:1 by volume mixture of hexane and ethyl acetate as the eluent, to give 2.11 g (yield 59%) of 3-(3-chlorophenyl)-2-propenal as a solid.

1. temperatureunder reflux for 5 hours
2. concentrationAt the end of this time, the reaction mixture was concentrated by evaporation under reduced pressure
3. customthe resulting residue was purified by column chromatography through silica gel
4. additionby volume mixture of hexane and ethyl acetate as the eluent