反应详情

Following a procedure similar to that described in the final part of Preparation 15, a solution of 3.04 g of this 1-(2-benzyloxyphenyl)-4-(3-chlorophenyl)butane in 18 ml of methylene chloride was treated with 8.67 ml of a 1M solution of boron tribromide in methylene chloride to eliminate the benzyl group. The resulting crude product was purified by column chromatography through silica gel, using a 4:1 by volume mixture of hexane and ethyl acetate as the eluent, to give 1.82 g (yield 80%) of the title compound as a colorless oil.

1. custompart of Preparation 15
2. customThe resulting crude product was purified by column chromatography through silica gel
3. additionby volume mixture of hexane and ethyl acetate as the eluent