反应详情

Finally, following a procedure similar to that described in the final part of Preparation 15, the whole of this 1-(2-benzyloxyphenyl)-4-(2-chlorophenyl)butane was dissolved in 18 ml of methylene chloride and debenzylated by means of 8.15 ml of a 1M solution of boron tribromide in methylene chloride. The crude product thus obtained was purified by column chromatography through silica gel, using a 4:1 by volume mixture of hexane and ethyl acetate as the eluent, to give 2.0 g (yield 94%) of the title compound as a colorless solid.

1. custompart of Preparation 15
2. customThe crude product thus obtained
3. customwas purified by column chromatography through silica gel
4. additionby volume mixture of hexane and ethyl acetate as the eluent