Boron tribromide → HCID 10537566, compound

Participants

Reaction Steps

The whole of this benzyl 2-[2-(3-chlorophenyl)ethyl]phenyl ether was dissolved in 50 ml of methylene chloride, and 17 ml of a 1M solution of boron tribromide in methylene chloride were added to the solution, whilst ice-cooling. The mixture was then allowed to stand at room temperature for 2 hours. At the end of this time, the solvent was removed by distillation under reduced pressure, and the resulting residue was purified by column chromatography through silica gel, using a 10:1 by volume mixture of hexane and ethyl acetate as the eluent, to give 3.80 g (yield 99%) of the title compound as a solid.

Provenance & Evidence