反应详情

A solution of 2- (aminosulfonylamino) pentanoic acid methyl ester (10.5 g; 0.05 mmol) in methanol (100 ml) was added to a solution of sodium methoxide (3.78 g, from 1.61 g of Na) in 100 ml of methanol and the resulting reaction mixture was refluxed for 18 hours. The mixture was cooled, neutralized with BIO-RAD® 50W-X8 H+ ion exchange resin, and filtered. The filtrate was concentrated in vacuo to yield an oil which was crystallized from methanol/hexane to afford 6.5 g (73%) of 4-propyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide (Formula IV: R1 =H; R2 =propyl; R3 =H).

1. customthe resulting reaction mixture
2. temperaturewas refluxed for 18 hours
3. temperatureThe mixture was cooled
4. filtrationfiltered
5. concentrationThe filtrate was concentrated in vacuo
6. customto yield an oil which
7. customwas crystallized from methanol/hexane