N-(carbobenzyloxyaminosulfonyl)-2-propyl-DL-alanine methyl ester → N-aminosulfonyl-2-propyl-DL-alanine methyl ester

Participants

Reaction Steps

A mixture of N-(carbobenzyloxyaminosulfonyl)-2-propyl-DL-alanine methyl ester (22.35 g, 62.36 mmol), methanol (200 mL) and 10% palladium on Carbon (1.0 g) was placed on a Parr hydrogenator at 60 psi for 1.5 hours. The reaction mixture was passed through a pad of CELITE®, and the filtrate was concentrated in vacuo to afford 11.16 g (79.8%) of N-aminosulfonyl-2-propyl-DL-alanine methyl ester (Formula VII: R=CH3 ; R1 =propyl; R2 =CH3; R3 =H).

Provenance & Evidence