反应详情

A solution of N-(carbobenzyloxyaminosulfonyl)-2-(3-methyl-3-chlorobutyl)-sarcosine methyl ester (23.61 g, 55.96 mmol) in 200 ml of methanol under nitrogen was cooled to 0° C. and 1.0 g of 10% Pd/C was added. The mixture was placed into a Parr Apparatus and hydrogenated at 50 psi for 4 hours. The catalyst was removed on a pad of CELITE® and the filtrate was concentrated in vacuo to afford 15.23 g (94.9%) of N-(aminosulfonyl)-2-(3-methyl-3-chlorobutyl)-sarcosine methyl ester (Formula VII: R=CH3 ; R1 =H; R2 =(CH2)2C (Cl) (CH3)2 ; R3 =CH3) as an oil.

1. customThe catalyst was removed on a pad of CELITE®
2. concentrationthe filtrate was concentrated in vacuo