Dichloromethane → HCID 19424400, compound

Participants

Reaction Steps

To a solution of 2-phenylthiomethyl-4-phenylmethyl-5-methyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide (11.78 g, 33.05 mmol) in 200 ml of methylene chloride was added in one portion under nitrogen sulfuryl chloride (3.15 ml, 39.66 mmol) and the mixture was stirred for 3.5 hours at room temperature. The mixture was concentrated in vacuo and the residue was triturated in hexane and purified by flash chromatography (20% ethyl acetate in hexane) to afford 8.82 g (92.4%) of 2-chloromethyl-4-phenylmethyl-5-methyl-1,2,5-thiadiazolidin-3-one (Formula II: R1 =H; R2 =CH2Ph; R3 =CH3 ; X'=Cl) as an oil.

Provenance & Evidence