HCID 19424454, compound → HCID 19424399, compound

Participants

Reaction Steps

A solution of ethyl N-(carbobenzyloxyaminosulfonyl)-2-azabicyclo[2,2,1]heptan-3-carboxylate (40.35 g; 105.51 mmol) in methanol (300 ml) under nitrogen was cooled to 0° C. and 2.5 g of 10% Pd/C was added. The mixture was placed into a Parr Apparatus and hydrogenated for 3 hours at 50 psi. The catalyst was removed on a pad of CELITE® and the filtrate was concentrated in vacuo and purified by flash silica gel chromatography (35-40% ethyl acetate/hexane) to afford 22.79 g (87%) of ethyl N-(aminosulfonyl)-2-azabicyclo[2,2,1]heptan-3-carboxylate (Formula VII: R=Ethyl; R1 =H; R2 and R3 together = ##STR19## as a solid.

Provenance & Evidence