Acetonitrile → HCID 67317069, compound

HRID 74351Notes

Reaction equation

HRID 74351 reaction equation
[CH2:1]([O:9][C:10]1[CH:11]=[C:12]([CH:15]=[CH:16][CH:17]=1)[CH:13]=[O:14])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[C:18](#[N:20])[CH3:19]>>[OH:14][CH:13]([C:12]1[CH:15]=[CH:16][CH:17]=[C:10]([O:9][CH2:1][CH2:2][C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:11]=1)[CH2:19][C:18]#[N:20]

Participants

3

Reactant 2

HCID 6342AcetonitrileHCID 17603797HCID 17603797, compound

Product 1

HCID 67317069HCID 67317069, compound

Procedure

Addition of acetonitrile to 3-phenethoxybenzaldehyde gave 3-hydroxy-3-(3-phenethoxyphenyl)propanenitrile as a yellow oil. Yield (0.80 g, 80%): 1H NMR (400 MHz, CDCl3) δ 7.23-7.38 (m, 6H), 6.93-6.97 (m, 2H), 6.88 (dd, J=7.6, 1.8 Hz, 1H), 5.00 (t, J=6.0 Hz, 1H), 4.18 (t, J=7.2 Hz, 2H), 3.12 (t, J=7.2 Hz, 2H), 2.75 (d, J=6.4 Hz, 2H).

Sources & evidence

ORD record
ord-642fd4b368ee4466b1cbd594faa4335f
Source dataset
uspto-grants-2014_09
Patent number
US08829244B2

Reaction notes

Loading…