Sodium Azide → (S)-1-azido-3-(3-(2-propylpentyloxy)phenyl)propan-2-ol

HRID 74361Notes

Reaction equation

HRID 74361 reaction equation
Cl[CH2:2][C@@H:3]([OH:20])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][CH2:12][CH:13]([CH2:17][CH2:18][CH3:19])[CH2:14][CH2:15][CH3:16])[CH:6]=1.[N-:21]=[N+:22]=[N-:23].[Na+]>>[N:21]([CH2:2][C@@H:3]([OH:20])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][CH2:12][CH:13]([CH2:17][CH2:18][CH3:19])[CH2:14][CH2:15][CH3:16])[CH:6]=1)=[N+:22]=[N-:23]

Participants

3

Reactant 2

HCID 33557Sodium AzideHCID 67318055(S)-1-chloro-3-(3-(2-propylpentyloxy)phenyl)propan-2-ol

Product 1

HCID 86637617(S)-1-azido-3-(3-(2-propylpentyloxy)phenyl)propan-2-ol

Procedure

Treatment of (S)-1-chloro-3-(3-(2-propylpentyloxy)phenyl)propan-2-ol with sodium azide following the method used in Example 66 gave (S)-1-azido-3-(3-(2-propylpentyloxy)phenyl)propan-2-ol which was used without further purification.

Sources & evidence

ORD record
ord-43b32ef6ae1f4277a4ee7a39fdb9e73e
Source dataset
uspto-grants-2014_09
Patent number
US08829244B2

Reaction notes

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