Methacrylic Acid → HCID 15375485, compound

Participants

Reaction Conditions

Reaction Steps

Into a 3 liter flask, 1560 g of 4-amino-2,2,6,6-tetramethylpiperidine was placed. After the temperature was raised to 145° C., 430 g of methacrylic acid was added dropwise thereto. The inner temperature rose gradually and then the reaction mixture was kept at 170°±5° C., while collecting water distilled off, until the water collected had amounted to 90 g. Then the reaction mixture was cooled down to 50° C., and 500 g of acetone was added to the mixture to obtain a light yellowish slurry. The slurry thus obtained was cooled down to 20° C. and filtered. The filter cake was washed with acetone and dried to obtain 1053 g of pure white 2-methyl-3-(2,2,6,6-tetramethyl-4-piperidylamino)-N-(2,2,6,6-tetramethyl-4-piperidyl)propionamide (hereinafter referred to as Compound 1). M.p.: 115.5°-116.5° C. Mass spectrometry (FD-MS): m/z 380 (M+).

Provenance & Evidence