7,8,9-Trifluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine-3-carboxylic acid → 7,9-Difluoro-1-methyl-8-(3-methylamino-1-azetidinyl)-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine-3-carboxylic acid

HRID 743665Notes

Reaction equation

HRID 743665 reaction equation
[F:1][C:2]1[C:20](F)=[C:19]([F:22])[C:5]2=[N:6][C:7]3[N:8]([CH3:18])[CH:9]=[C:10]([C:15]([OH:17])=[O:16])[C:11](=[O:14])[C:12]=3[CH:13]=[C:4]2[CH:3]=1.Cl.Cl.[CH3:25][NH:26][CH:27]1[CH2:30][NH:29][CH2:28]1>>[F:1][C:2]1[C:20]([N:29]2[CH2:30][CH:27]([NH:26][CH3:25])[CH2:28]2)=[C:19]([F:22])[C:5]2=[N:6][C:7]3[N:8]([CH3:18])[CH:9]=[C:10]([C:15]([OH:17])=[O:16])[C:11](=[O:14])[C:12]=3[CH:13]=[C:4]2[CH:3]=1

Participants

3

Reactant 2

HCID 194236787,8,9-Trifluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine-3-carboxylic acidHCID 22121158N-methylazetidin-3-amine dihydrochloride

Product 1

HCID 194237637,9-Difluoro-1-methyl-8-(3-methylamino-1-azetidinyl)-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine-3-carboxylic acidYield 84.5%

Procedure

7,9-Difluoro-1-methyl-8-(3-methylamino-1-azetidinyl)-4-oxo-1,4-dihydrobenzo[b][1,8]-naphthyridine-3-carboxylic acid was prepared under the conditions of Example 30, but starting with 1.5 g of 7,8,9-trifluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine-3-carboxylic acid and 1.2 g of 3-(methylamino)azetidine dihydrochloride. 1.54 g of 7,9-difluoro-1-methyl-8-(3-methylamino-1-azetidinyl)-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine-3-carboxylic acid are obtained in the form of a yellow solid, which decomposes at 302° C.

Workup

  1. custom7,9-Difluoro-1-methyl-8-(3-methylamino-1-azetidinyl)-4-oxo-1,4-dihydrobenzo[b][1,8]-naphthyridine-3-carboxylic acid was prepared under the conditions of Example 30

Sources & evidence

ORD record
ord-a15d5dc80f3d49b195fb4c72477e73c5
Source dataset
uspto-grants-1996_09
Patent number
US05556861

Reaction notes

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