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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 743687Generated: October 30, 2026

Sulfuryl chloride → 3-Methoxycarbonyl-4-chloro-5-difluoromethoxy-1-methylpyrazole

https://huagongshe.com/reaction/743687

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSulfuryl chlorideHCID 24648—
ReactantMethyl 5-(difluoromethoxy)-1-methyl-1H-pyrazole-3-carboxylateHCID 54319416—
SolventDichloromethaneHCID 6344—
Product3-Methoxycarbonyl-4-chloro-5-difluoromethoxy-1-methylpyrazoleHCID 53735123—

Reaction Steps

2.1 g (10 mmole) 3-Methoxycarbonyl-5-difluoromethoxy-1-methylpyrazole, dissolved in 30 ml methylene chloride, was treated with 1.35 g (10 mmole) sulfuryl chloride and stirred for 10 minutes at room temperature. It was then concentrated and recrystallised from diisopropyl ether/ethyl acetate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05556986
Source datasetuspto-grants-1996_09
ORD IDord-62653675b6724c74a531ec7d80657dd4
Source noteuspto-grants-1996_09