HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromo-1-propanol → 2-(3-(3-(3-Hydroxypropoxy)phenyl)propyl)isoindoline-1,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromo-1-propanol | HCID 12308 | — |
| Reactant | 2-[3-(3-Hydroxyphenyl)propyl]isoindole-1,3-dione | HCID 58027542 | — |
| Product | 2-(3-(3-(3-Hydroxypropoxy)phenyl)propyl)isoindoline-1,3-dione | HCID 67317438 | — |
Reaction Steps
Alkylation reaction of phenol 58 with 3-bromo-1-propanol gave 2-(3-(3-(3-hydroxypropoxy)phenyl)propyl)isoindoline-1,3-dione as yellow oil. Yield (0.300 g, 25%): 1H NMR (400 MHz, CDCl3) δ 7.80-7.83 (m, 2H), 7.69-7.71 (m, 2H), 7.12-7.16 (m, 1H), 6.78 (d, J=7.6 Hz, 1H), 6.76 (s, 1H), 6.65 (dd, J=8.0, 2.4 Hz, 1H), 4.10 (d, J=6.0 Hz, 2H), 3.84-3.89 (m, 2H), 3.73 (t, J=7.2 Hz, 2H), 2.65 (t, J=8.0 Hz, 2H), 1.98-2.05 (m, 4H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08829244B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-44423e98cfff48eb8b97ae9a8698bd28 |
| Source note | uspto-grants-2014_09 |