Pyridine → HCID 21468971, compound

Participants

Reaction Steps

Triflic anhydride (71 mmoles, 20 g) was added at -27° C. to a solution of pyridine (74 mmoles, 5.9 g) in 150 ml methylene chloride with vigorous stirring. The solution was warmed to room temperature. Benzyl 2-hydroxyhexanoic acid (57 mmoles, 12.65 g) in 15 ml methylene chloride was added over 2 minutes. The solution was stirred for 1 hour and filtered. The filtrate was concentrated, filtered through silica gel eluted with hexane, and evaporated to yield 17.0 g of benzyl 2-(trifluoromethanesuifonylhydroxy)hexanoic acid. (MS)

Provenance & Evidence