HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dicyclohexylcarbodiimide → L-Proline, 4,4-dimethoxy-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 4,4-Dimethoxy-L-proline methyl ester | HCID 11137904 | — |
| Reactant | 2-[5-[2-(2H-tetrazol-5-yl)phenyl]benzimidazol-1-yl]octanoic acid | HCID 15838180 | — |
| Reactant | HCID 178418300 | HCID 178418300 | — |
| Product | L-Proline, 4,4-dimethoxy- | HCID 12821175 | — |
Reaction Steps
4,4-Dimethoxy-L-proline methyl ester (1.35 mmoles, 0.257 g) and 2-[5-[2-(2H-tetrazol-5-yl)phenyl]-1H-benzimidazol-1-yl]octanoic acid (1.23 mmoles, 0.5 g) were reacted in the presence of hydroxybenzotriazole and dicyclohexylcarbodiimide as in Example 15 to yield 0.220 g of 1-[1-oxo-2-[5-2-(2H-tetrazol-5-yl)phenyl]-1H-benzimidazol-1-yl]octyl]-4,4-dimethoxy-L-proline. (MS).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05556981 |
| Source dataset | uspto-grants-1996_09 |
| ORD ID | ord-3587088e8ba044acad31b68e3d838768 |
| Source note | uspto-grants-1996_09 |