Potassium Hydroxide → HCID 178493560, compound

HRID 743980Notes

Reaction equation

HRID 743980 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([SH:11])[N:4]=1.[OH-].[K+].[N+]([N:17]1[CH:21]=[C:20]([N+:22]([O-:24])=[O:23])[C:19]([CH3:25])=[N:18]1)([O-])=O>O.C(O)C>[CH3:10][O:9][C:7]1[CH:8]=[C:3]([O:2][CH3:1])[N:4]=[C:5]([S:11][C:21]2[NH:17][N:18]=[C:19]([CH3:25])[C:20]=2[N+:22]([O-:24])=[O:23])[N:6]=1

Participants

6

Reactant 3

HCID 14797Potassium HydroxideHCID 39944183-methyl-1,4-dinitropyrazoleHCID 178493561HCID 178493561, compound

Product 1

HCID 178493560HCID 178493560, compoundYield 78.5%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

4,6-Dimethoxy-2-mercaptopyrimidine (4.65 g) was dissolved in water containing potassium hydroxide (1.7 g in 75 mls of water). 1,4-Dinitro-3-methylpyrazole (4.65 g) dissolved in the minimum of ethanol was then added dropwise. After the exothermic reaction had subsided, the mixture was stirred for 45 minutes. The precipitated solid was filtered off, washed with fresh water, and dried to give 6.3 g of the desired product, mp 175°-6° C.

Workup

  1. additionwas then added dropwise
  2. customAfter the exothermic reaction
  3. filtrationThe precipitated solid was filtered off
  4. washwashed with fresh water
  5. customdried

Sources & evidence

ORD record
ord-a71f3f4234544da0a7aace752bbf3d04
Source dataset
uspto-grants-1996_09
Patent number
US05559081

Reaction notes

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