反应详情

Methyl (chlorosulfonyl)acetate (13.0 g) in dichloromethane (20 ml) was added dropwise with stirring and cooling to 2-(4,6-dimethoxypyrimidin-2-yloxy)-6-fluoroaniline (20 g) and pyridine (6.3 g) in dichloromethane (120 ml). After stirring for 2 hours, the mixture was allowed to stand at room temperature overnight. Washing with dilute hydrochloric acid and water, drying over magnesium sulfate, and running down, gave an oil which was triturated with ether. The resulting off-white solid was separated by filtration to give 20.4 g of the desired product, mp 111°-114° C.

1. stirringAfter stirring for 2 hours
2. washWashing with dilute hydrochloric acid and water
3. dry with materialdrying over magnesium sulfate
4. customgave an oil which
5. customwas triturated with ether
6. customThe resulting off-white solid was separated by filtration