Water → 1-Benzyloxy-3-chloro-7-cyano-6-trifluoromethylquinoxalin-2(1H)-one

Participants

Reaction Steps

To a solution of 7.0 g (~19.4 mmol) of 1-benzyloxy-7-cyano-6-trifluoromethylquinoxaline-2,3(1H,4H)-dione in 250 ml of dry N,N-dimethylformamide was added at 0° C. 38.5 ml of 1.93M phosgene in toluene (~74.3 mmol). Stirring was continued at 24° C. for 20 h. The evaporated reaction mixture was stirred with water to give the title compound (6.6 g; 89%).

Provenance & Evidence