HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 744012Generated: October 29, 2026
Hydrazine hydrate (1:1) → 1-Benzyloxy-3-hydrazino-7-trifluoromethylquinoxalin-2(1H)-one
https://huagongshe.com/reaction/744012
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 1-Benzyloxy-3-chloro-7-trifluoromethylquinoxalin-2(1H)-one | HCID 19421447 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Benzyloxy-3-hydrazino-7-trifluoromethylquinoxalin-2(1H)-one | HCID 19421407 | 85.6% |
Reaction Steps
A mixture of 1-benzyloxy-3-chloro-7-trifluoromethylquinoxalin-2(1H)-one (27 g, 76 mmol) and hydrazine hydrate (14.7 ml, 0.30 mol) in 250 ml of dichloromethane was stirred at 0° C. for 2 h. The precipitate was isolated by filtration, washed with dichloromethane and water and dried to give 22.8 g (76%) of the title compound. M.p. 174°-176° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05559106 |
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| Source dataset | uspto-grants-1996_09 |
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| ORD ID | ord-c0534d16434d486e9a6801067c32940f |
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| Source note | uspto-grants-1996_09 |
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