Bromine → HCID 19421441, compound

Participants

Reaction Steps

A mixture of 1-[1-(diethoxyphosphoryl)ethyl]-7-trifluoromethyl[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one (811 mg, 1.94 mmol), silver sulfate (605 mg, 1.94 mmol) and bromine (100 μl, 1.94 mmol) in 5 ml of conc. sulfuric acid was stirred overnight at room temperature. The mixture was filtered and the filtrate was added dropwise to 100 ml of ice/water. The resulting precipitate was isolated by filtration, washed with water and dried to give 514 mg (53%) of the title compound; m.p.>200° C., decomp. 1H-NMR (DMSO-d6): δ 1.12 (t, 3H), 1.18 (t, 3H), 1.74 (dd, 3H), 3.95 (quint, 2H), 4.07 (quint, 2H), 4.78 (dq, 1H), 7.81 (s, 1H), 8.59 (s, 1H), 12.35 (s, 1H).

Provenance & Evidence