HRID744152

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1110

Butanedioic acid

C4H6O4

HCID9884122

未命名化合物

PRODUCTS

产物

HCID131719486

未命名化合物

收率 163.1%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

2 次

PROCEDURE

实验过程

A solution of succinic acid (69 mg) in hot ethanol (3.5 mL) was added slowly with stirring to a solution of (R)-5-(2-ethylsulphonylethyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole free base (390 mg) in ethanol (3.5 mL). The solution was evaporated and the residue was triturated first with ether and then with ethyl acetate to give the title compound as a solid (375 mg): mp 59°-62° C.: [α]25D =+36° (methanol, c=0.10) Anal Calcd for C18H26N2O2S. 0.5 C4H6O4. 0.25 CH3CO2C2H5. 0.5 H2O: C,59.00; H,7.42; H,6.68. Found: C,59.17; H,7.37; N,6.73.

WORKUP

后处理

customThe solution was evaporated
customthe residue was triturated first with ether

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-0cbe4f0cf15940408d1c2a8063614b2c
来源数据集: uspto-grants-1996_09
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US05559129
来源说明: uspto-grants-1996_09

反应SMILES

[C:1]([OH:8])(=[O:7])[CH2:2][CH2:3][C:4]([OH:6])=[O:5].[CH2:9]([S:11]([CH2:14][CH2:15][C:16]1[CH:17]=[C:18]2[C:22](=[CH:23][CH:24]=1)[NH:21][CH:20]=[C:19]2[CH2:25][C@H:26]1[CH2:30][CH2:29][CH2:28][N:27]1[CH3:31])(=[O:13])=[O:12])[CH3:10]>C(O)C>[C:1]([OH:8])(=[O:7])[CH2:2][CH2:3][C:4]([OH:6])=[O:5].[CH2:9]([S:11]([CH2:14][CH2:15][C:16]1[CH:17]=[C:18]2[C:22](=[CH:23][CH:24]=1)[NH:21][CH:20]=[C:19]2[CH2:25][C@H:26]1[CH2:30][CH2:29][CH2:28][N:27]1[CH3:31])(=[O:13])=[O:12])[CH3:10].[CH2:9]([S:11]([CH2:1][CH2:2][C:3]1[CH:4]=[C:18]2[C:22](=[CH:23][CH:24]=1)[NH:21][CH:20]=[C:19]2[CH2:25][C@H:26]1[CH2:30][CH2:29][CH2:28][N:27]1[CH3:31])(=[O:13])=[O:12])[CH3:10]