HCID 13563154, compound → HCID 466466, compound

HRID 744161Notes

Reaction equation

HRID 744161 reaction equation
C([O:9][C@H:10]1[C@@H:14]([O:15]C(=O)C2C=CC=CC=2)[C@H:13]([CH2:24][O:25]C(=O)C2C=CC=CC=2)[O:12][C@@H:11]1[N:34]1[CH:41]=[CH:40][C:38](=[O:39])[NH:37][C:35]1=[O:36])(=O)C1C=CC=CC=1>N.CO>[C@H:11]1([N:34]2[CH:41]=[CH:40][C:38](=[O:39])[NH:37][C:35]2=[O:36])[O:12][C@@H:13]([CH2:24][OH:25])[C@H:14]([OH:15])[C@@H:10]1[OH:9]

Participants

3

Reactant 1

HCID 13563154HCID 13563154, compound

Product 1

HCID 466466HCID 466466, compoundYield 87.9%

Reagents, catalysts & solvents 1

HCID 21705897Ammonia methanolSolvent

Procedure

Compound 3 (0.87 g, 1.56 mmol) in NH3 /MeOH (100 ml) was stirred at room temperature overnight. The solvent was evaporated and the residue was dissolved in H2O (50 ml), washed with ether (3×25 ml). and evaporated to give a white solid and it was crystallized from 95% EtOH to give pure compound 4 (0.335 g, 87.2%) as white crystal: m.p. 165°-166° C.

Workup

  1. customThe solvent was evaporated
  2. dissolutionthe residue was dissolved in H2O (50 ml)
  3. washwashed with ether (3×25 ml)
  4. customand evaporated
  5. customto give a white solid and it
  6. customwas crystallized from 95% EtOH

Sources & evidence

ORD record
ord-d85a85c8d27f4f909443e1bd887c4c1f
Source dataset
uspto-grants-1996_09
Patent number
US05559101

Reaction notes

Loading…