Phosphorus sulfide (P2S5) → HCID 22865603, compound

Participants

Reaction Steps

Phosphorus pentasulfide (5.99 g, 26.95 mmol) was added to a solution of compound 18 (3.75 g, 6.73 mmol) inpyridine (70 ml) and was refluxed for four hours. After cooling, the solvent was evaporated and the residue dissolved in CHCl3, washed with water and brine. After drying over anhydrous Na2SO 4, evaporation of the solvent gave the crude product which was purified on a silica gel column using 30% EtOAc/petroleum ether as solvent to give compound 19 (3.68 g, 95%) as golden yellow foam.

Provenance & Evidence