Boron Trichloride → HCID 53799376, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 24 (1.0 g, 1.87 mmol) in CH2Cl2 (50 ml), at -78° C. under nitrogen atmosphere, 1M solution of BCl3 (20 ml, 20.57 mmol) was added dropwise. The reaction mixture was stirred at -78° C. for four hours, a 1:1 mixture of CH2Cl2 /MeOH (50 ml) was added and the reaction mixture was brought to room temperature and the solvents were evaporated to dryness. The residue was coevaporated with MeOH (25 ml) 5 times. The residue obtained was dissolved in water and washed with CHCl3 (2×50 ml). The water layer was evaporated to give a white solid which was crystallized from EtOH/ether to give the pure 25 (0.41 g, 83%) as white crystals: m.p. 150° C.

Provenance & Evidence