Sodium Hydroxide → HCID 67578202, compound

Participants

Reaction Steps

Add 5 g of 2-chloro-4-methoxyphenol to a mixture of 17 g of α,α'-dibromo-p-xylene to a stirred mixture of 2.5 g of 50:50 (w/w) NaOH:H20 and 50 mL of DMF. Stir the so-formed mixture for 4 hours. Partition the reaction mixture with methylene chloride and water. Separate the organic layer and remove the solvent by rotary evaporation to obtain a solid residue. Purify the residue on a silica gel chromatography column using pure hexane to pure methylene chloride as the eluants to provide 8 g of 1-[4-bromomethylbenzyloxy]-2-chloro-4methoxyphenyl ether.

Provenance & Evidence