HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexane, (bromomethyl)- → 1-Bromo-3-(cyclohexylmethoxy)-5-fluorobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexane, (bromomethyl)- | HCID 137636 | — |
| Reactant | 3-Bromo-5-fluorophenol | HCID 21904636 | — |
| Product | 1-Bromo-3-(cyclohexylmethoxy)-5-fluorobenzene | HCID 67317171 | — |
Reaction Steps
Alkylation of 3-bromo-5-fluorophenol using (bromomethyl)cyclohexane following the method used in Example 1 gave 1-bromo-3-(cyclohexylmethoxy)-5-fluorobenzene. Yield (1.1 g, 73%): 1H NMR (400 MHz, CDCl3) δ 6.79-6.83 (m, 2H), 6.52 (dt, J=10.4, 2.0 Hz, 1H), 3.70 (d, J=6.0 Hz, 2H), 1.65-1.86 (m, 6H), 1.16-1.34 (m, 3H), 0.97-1.08 (m, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08829244B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-313493064294469498135ccfaeaa7e6c |
| Source note | uspto-grants-2014_09 |