Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 3-(4-Piperidyl)-6-fluoro-1,2-benzisoxazole | HCID 849421 | — |
| Reactant | 4-(3-Chloropropoxy)-3-methoxyphenyl-2-hydroxyethanone | HCID 18467332 | — |
| Product | HCID 67652749 | HCID 67652749 | — |
Reaction Steps
A mixture of 3-(4-piperidinyl)-6-fluoro-1,2-benzisoxazole (1.3 g, 5.8 mmol), 1-[4-(3-chloropropoxy)-3-methoxyphenyl]-2-hydroxyethanone (1.5 g, 5.8 mmol), NaHCO3 (1.5 g) and 1-methyl-2-pyrrolidinone (50 ml) was stirred under N2 at 100° C. for 6 hours. The reaction was poured into H2O, and the aqueous suspension was extracted with EtOAc. The extract was washed (H2O), dried (MgSO4) and concentrated to afford the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05559116 |
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| Source dataset | uspto-grants-1996_09 |
|---|
| ORD ID | ord-56bd4c4663394425b7c3176b4e291093 |
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| Source note | uspto-grants-1996_09 |
|---|
