(Diethylamino)sulfur trifluoride → Tert-butyl 3-(3-(cyclohexylmethoxy)phenyl)-2-fluoropropylcarbamate

HRID 74434Notes

Reaction equation

HRID 74434 reaction equation
[CH:1]1([CH2:7][O:8][C:9]2[CH:10]=[C:11]([CH2:15][CH:16](O)[CH2:17][NH:18][C:19](=[O:25])[O:20][C:21]([CH3:24])([CH3:23])[CH3:22])[CH:12]=[CH:13][CH:14]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.CCN(S(F)(F)[F:33])CC>>[CH:1]1([CH2:7][O:8][C:9]2[CH:10]=[C:11]([CH2:15][CH:16]([F:33])[CH2:17][NH:18][C:19](=[O:25])[O:20][C:21]([CH3:24])([CH3:23])[CH3:22])[CH:12]=[CH:13][CH:14]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 123472(Diethylamino)sulfur trifluorideHCID 58027630HCID 58027630, compound

Product 1

HCID 67317096Tert-butyl 3-(3-(cyclohexylmethoxy)phenyl)-2-fluoropropylcarbamate

Procedure

tert-Butyl 3-(3-(cyclohexylmethoxy)phenyl)-2-hydroxypropylcarbamate and DAST are reacted together to give tert-butyl 3-(3-(cyclohexylmethoxy)phenyl)-2-fluoropropylcarbamate.

Sources & evidence

ORD record
ord-6be131337c3d4e66af1b7ad7fcff4893
Source dataset
uspto-grants-2014_09
Patent number
US08829244B2

Reaction notes

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