4-(Methylthio)phenylhydrazine → 3-(4-Fluorophenyl)-1-(4-methylsulfinylphenyl)-4-(4-pyridyl)-5H-pyrazole

HRID 744461Notes

Reaction equation

HRID 744461 reaction equation
N[C:2]1N(C2SC=CC=2C)N=[C:4]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[C:3]=1[C:20]1[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=1.[CH3:26][S:27][C:28]1[CH:33]=[CH:32][C:31]([NH:34][NH2:35])=[CH:30][CH:29]=1.FC1C=CC(C(=[O:53])C(C2C=CN=CC=2)C#N)=CC=1>>[F:19][C:16]1[CH:17]=[CH:18][C:13]([C:4]2[NH:35][N:34]([C:31]3[CH:32]=[CH:33][C:28]([S:27]([CH3:26])=[O:53])=[CH:29][CH:30]=3)[CH2:2][C:3]=2[C:20]2[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=2)=[CH:14][CH:15]=1

Participants

4

Reactant 3

HCID 27609784-(Methylthio)phenylhydrazineHCID 186256553-(4-Fluorophenyl)-3-oxo-2-(4-pyridinyl)propanenitrileHCID 676350455-Amino-3-(4-fluorophenyl)-1-(methylthiophenyl)-4-(4-pyridyl)pyrazole

Product 1

HCID 220375003-(4-Fluorophenyl)-1-(4-methylsulfinylphenyl)-4-(4-pyridyl)-5H-pyrazole

Procedure

5-Amino-3-(4-fluorophenyl)-1-(methylthiophenyl)-4-(4-pyridyl)pyrazole--The title compound is prepared following the procedure of Smith, P. A. S. et al., J. Org. Chem., 1970, 35 (7), 2215 except using 4-(methylthio)phenylhydrazine hydrochloide and 3-(4-fluorophenyl)-3-oxo-2-(pyridin-4-yl)propanenitrile.

Sources & evidence

ORD record
ord-93ce50cc25474832b1c0db7b391c3bb2
Source dataset
uspto-grants-1996_09
Patent number
US05559137

Reaction notes

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