Ethanol → Pyridine, 3-(4-ethoxy-1,2,5-thiadiazol-3-yl)- (9CI)

Participants

Role	Name	HCID	Charge
Reactant	Ethanol	HCID 702	—
Reactant	Sodium	HCID 5360545	—
Reactant	3-Chloro-4-(pyridin-3-yl)-1,2,5-thiadiazole	HCID 10488164	—
Product	Pyridine, 3-(4-ethoxy-1,2,5-thiadiazol-3-yl)- (9CI)	HCID 15180131	76%

Reaction Conditions

Temperature	40 °C

Reaction Steps

To a solution of sodium (440 mg, 17 mmol) in ethanol (10 ml) was added 3-(4-chloro-1,2,5-thiadiazol-3-yl)pyridine (540 mg, 3.3 mmol). The mixture was stirred at 40° C. for 10 h and evaporated. The residue was dissolved in water and extracted with methylene chloride. The combined organic phases were dried and evaporated to yield 520 mg (76%) of the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05559138
Source dataset	uspto-grants-1996_09
ORD ID	ord-938932b56ca4404aa05b942ddf853ee3
Source note	uspto-grants-1996_09