1-Hexanol → 3-(4-(Hexyloxy)-1,2,5-thiadiazol-3-yl)pyridine

Participants

Role	Name	HCID	Charge
Reactant	1-Hexanol	HCID 8103	—
Reactant	Sodium	HCID 5360545	—
Reactant	3-Chloro-4-(pyridin-3-yl)-1,2,5-thiadiazole	HCID 10488164	—
Product	3-(4-(Hexyloxy)-1,2,5-thiadiazol-3-yl)pyridine	HCID 15180135	—

Reaction Conditions

Temperature	50 °C

Reaction Steps

To a solution of sodium (230 mg, 10 mmol) in 1-hexanol (15 ml) was added 3-(4-chloro-1,2,5-thiadiazol-3-yl)pyridine (490 mg, 2.5 mmol). The mixture was stirred at 50° C. for 2 h and evaporated. The residue was dissolved in water and extracted with ether. The combined organic phases were dried and evaporated to give the wanted compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05559138
Source dataset	uspto-grants-1996_09
ORD ID	ord-8ccdcb7785cc4e6cba55ef707f2a2bbc
Source note	uspto-grants-1996_09