Methyl iodide → 3-(3-Cyclopropylmethoxy-1,2,5-thiadiazol-4-yl)-1-methylpyridinium iodide

HRID 744616Notes

Reaction equation

HRID 744616 reaction equation
[CH3:1][I:2].[CH:3]1([CH2:6][O:7][C:8]2[C:9]([C:13]3[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=3)=[N:10][S:11][N:12]=2)[CH2:5][CH2:4]1>CC(C)=O>[I-:2].[CH:3]1([CH2:6][O:7][C:8]2[C:9]([C:13]3[CH:14]=[N+:15]([CH3:1])[CH:16]=[CH:17][CH:18]=3)=[N:10][S:11][N:12]=2)[CH2:4][CH2:5]1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 190752393-(3-Cyclopropylmethoxy-1,2,5-thiadiazol-4-yl)pyridine

Product 1

HCID 190754673-(3-Cyclopropylmethoxy-1,2,5-thiadiazol-4-yl)-1-methylpyridinium iodide

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of methyl iodide (0.25 ml, 4 mmol) and 3-(4-cyclopropylmethoxy-1,2,5-thiadiazol-3-yl )pyridine (400 mg, 1.7 mmol) in acetone (5 ml) was stirred at room temperature for 36 h. The title compound precipitated from the solution and was collected by filtration to yield 0.41 g (65% ).

Workup

  1. customThe title compound precipitated from the solution
  2. filtrationwas collected by filtration
  3. customto yield 0.41 g (65% )

Sources & evidence

ORD record
ord-0da0269032a048ef9a2f552cce56f86e
Source dataset
uspto-grants-1996_09
Patent number
US05559138

Reaction notes

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