Methyl iodide → 3-(3-Amino-1,2,5-oxadiazol-4-yl)-1-methylpyridinium iodide

HRID 744670Notes

Reaction equation

HRID 744670 reaction equation
[NH2:1][C:2]1[C:3]([C:7]2[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=2)=[N:4][O:5][N:6]=1.[CH3:13][I:14]>CC(C)=O>[I-:14].[NH2:1][C:2]1[C:3]([C:7]2[CH:8]=[N+:9]([CH3:13])[CH:10]=[CH:11][CH:12]=2)=[N:4][O:5][N:6]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 14155234-Pyridin-3-yl-1,2,5-oxadiazol-3-amine

Product 1

HCID 190753223-(3-Amino-1,2,5-oxadiazol-4-yl)-1-methylpyridinium iodide

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a solution of 3-(4-amino-1,2,5-oxadiazol-3-yl)pyridine (870 mg, 5.3 mmol) in acetone (20 ml) was added methyl iodide (990 μl, 16 mmol) and the reaction mixture was stirred overnight at room temperature. The title compound precipitated and was collected by filtration (1.1 g, 69%).

Workup

  1. customThe title compound precipitated
  2. filtrationwas collected by filtration (1.1 g, 69%)

Sources & evidence

ORD record
ord-0180e53f0ee0442d8b2fc5f4299999bb
Source dataset
uspto-grants-1996_09
Patent number
US05559138

Reaction notes

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