Water → HCID 19422083, compound

Participants

Reaction Steps

A solution of sodium bicarbonate (0.250 g), potassium iodide (0.050 g), and 6-bromo-N-[4-(trifluoromethyl)phenyl]hexanamide (1.00 g) in dimethylsulfoxide (15 mL) was heated at 125°-130° C. for 3.5 hours while stirring under a nitrogen atmosphere. The reaction was treated with water (75 mL) and extracted with ether. The ether extract was washed with brine (50 mL), dried over sodium sulfate after adding dichloromethane (30 mL), filtered, and concentrated in vacuo Chromatography using 50/50 ethyl acetate/hexane gave a white solid (Rf =0.2 in same solvent system, 0.326 g), identified as the title compound. m.p.: 129.5°-131.0° C.

Provenance & Evidence