HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 6-[[2-(5-Hydroxy-1H-indol-3-yl)ethyl]amino]-N-(3,4-dimethoxyphenyl)-heptanamide, monohydrochloride hydrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Serotonin Hydrochloride | HCID 160436 | — |
| Reactant | N-(3,4-dimethoxyphenyl)-6-oxo-heptanamide | HCID 15388978 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 6-[[2-(5-Hydroxy-1H-indol-3-yl)ethyl]amino]-N-(3,4-dimethoxyphenyl)-heptanamide, monohydrochloride hydrate | HCID 131717789 | — |
Reaction Steps
The compound was prepared as in Example 2B except using 178 mg of serotonin hydrochloride and using N-(3,4-dimethoxyphenyl)-6-oxo-heptanamide (225 mg), running the reaction 21 hours at ca. 25° C. The compound as the free amine had an Rf of 0.5 in 10:90 ethanol:ethyl acetate. The title compound was obtained as a tan solid (247 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05559143 |
| Source dataset | uspto-grants-1996_09 |
| ORD ID | ord-8a51cfcb7d234a128c347a2a1a6dcf49 |
| Source note | uspto-grants-1996_09 |