HCID 67770317, compound → HCID 178509742, compound

HRID 744717Notes

Reaction equation

HRID 744717 reaction equation
Cl.C([N:9]1[C:13]([C:14]([C:24]2[CH:29]=[CH:28][C:27]([C:30]#[N:31])=[CH:26][CH:25]=2)=[CH:15][CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:12][N:11]=[CH:10]1)C1C=CC=CC=1>C(O)C.[H][H].[Pd]>[C:30]([C:27]1[CH:26]=[CH:25][C:24]([CH:14]([C:13]2[N:9]=[CH:10][NH:11][CH:12]=2)[CH2:15][CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:29][CH:28]=1)#[N:31]

Participants

5

Reactant 1

HCID 67770317HCID 67770317, compound

Product 1

HCID 178509742HCID 178509742, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 702EthanolSolventHCID 178418361HCID 178418361, compoundSolvent

Procedure

1-benzyl-5-[1-(4-cyanophenyl)-4-phenyl-1-butenyl]-1H-imidazole hydrochloride (1,77 g) is dissolved in ethanol and a catalytic amount of 10% Pd/C is added. The reaction mixture is agitated vigorously at room temperature in hydrogen atmosphere until the reduction of the double bond and the debenzylation are complete. The reaction mixture is filtered and evaporated to dryness. The product is purified by flash chromatography.

Workup

  1. filtrationThe reaction mixture is filtered
  2. customevaporated to dryness
  3. customThe product is purified by flash chromatography

Sources & evidence

ORD record
ord-f0bed559b9974facb59482e4049ed898
Source dataset
uspto-grants-1996_09
Patent number
US05559141

Reaction notes

Loading…