1-Benzyl-1H-imidazole-5-carboxaldehyde → 1-benzyl-5-(4-(4-fluorophenyl)-1-hydroxybutyl]-1H-imidazole

HRID 744718Notes

Reaction equation

HRID 744718 reaction equation
Br[CH2:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][CH:6]=1.[CH2:12]([N:19]1[C:23]([CH:24]=[O:25])=[CH:22][N:21]=[CH:20]1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[CH2:12]([N:19]1[C:23]([CH:24]([OH:25])[CH2:2][CH2:3][CH2:4][C:5]2[CH:10]=[CH:9][C:8]([F:11])=[CH:7][CH:6]=2)=[CH:22][N:21]=[CH:20]1)[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 27732391-Benzyl-1H-imidazole-5-carboxaldehydeHCID 147371331-(3-Bromopropyl)-4-fluorobenzene

Product 1

HCID 194219941-benzyl-5-(4-(4-fluorophenyl)-1-hydroxybutyl]-1H-imidazole

Procedure

1-benzyl-5-[4-(4-fluorophenyl)-1-hydroxybutyl]-1H-imidazole is prepared from 1-bromo-3-(4-fluorophenyl)propane and 1-benzyl-5-imidazole carbaldehyde by the same method described in example 7a).

Sources & evidence

ORD record
ord-135e14674709476e9ebe6ece4229c210
Source dataset
uspto-grants-1996_09
Patent number
US05559141

Reaction notes

Loading…