Hydrochloric Acid → HCID 53880546, compound

Participants

Reaction Steps

With stirring at room temperature, 36 ml of 1N hydrochloric acid am added to a solution of 3.55 g of 2(R)-isopropyl-5(S)-[2(S)-isopropyl-3-(p-tert-butylphenyl)-propyl]-2,5-dihydro-3,6-dimethoxy-pyrazine in 35 ml of acetonitrile and the mixture is then stirred for a further 3 hours. The reaction solution is then poured onto a mixture of 45 ml of saturated NaHCO3 solution and ice and the suspension is extracted with dichloromethane. The extracts arc concentrated by evaporation and purified by FC (700 g of silica gel, eluant: dichloromethane/methanol/NH3 =200:10:1), yielding the title compound: Rf (dichloromethane/methanol/conc. ammonia=200:10:1)=0.70.

Provenance & Evidence