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HRID744790

反应详情

EQUATION

反应方程式

HRID 744790 的结构方程式

REACTANTS

反应物

3
结构：CO
HCID887

Methanol

CH4O

结构：O=S(=O)(O)O[O-].O=S(=O)(O)O[O-].O=S(=O)([O-])O.O=S(=O)([O-])[O-].[K+].[K+].[K+].[K+].[K+]
HCID15793144

Potassium hydrogen monopersulfate

H3K5O18S4

结构：CCCCNC(=O)C(C)C[C@H](O)[C@H](C[C@H](Cc1ccc(C(C)(C)C)c(OCSC)c1)C(C)C)NC(=O)OC(C)(C)C
HCID131719569

未命名化合物

PRODUCTS

生成物

1
结构：CCCCNC(=O)C(C)C[C@H](O)[C@H](C[C@H](Cc1ccc(C(C)(C)C)c(OCS(C)(=O)=O)c1)C(C)C)NC(=O)OC(C)(C)C
HCID131719570

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

CONDITIONS

反应条件

温度
0 °C

PROCEDURE

实验过程

With stirring at 0° C., a solution of 115 mg of potassium monopersulfate triple salt in 0.5 ml of water is added dropwise to a solution of 74 mg of N-tert-butoxycarbonyl-2(R,S)-methyl-4(S)-hydroxy-5(S)-amino-7(S)-isopropyl-8-[3-(methylthio-methoxy)-4-tert-butyl-phenyl]-octanoic acid (N-butyl)amide in 0.5 ml of methanol and the mixture is then stirred at room temperature for a further 20 hours. The reaction mixture is partitioned between dichloromethane and water. The organic phases are concentrated by evaporation and the title compound is obtained from the residue by FC (11 g of silica gel, ethyl acetate/hexane=1:1): Rf (ethyl acetate/hexane=1:1)=0.26; FAB-MS (M+H)+ =627.

WORKUP

后处理

  1. stirringthe mixture is then stirred at room temperature for a further 20 hours
  2. customThe reaction mixture is partitioned between dichloromethane and water
  3. concentrationThe organic phases are concentrated by evaporation