Hydrochloric Acid → 1-{3-[2-(1-Benzothiophen-5-yl)ethoxy]propyl}-3-pyrrolidinamine

HRID 7448Notes

Reaction equation

HRID 7448 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][CH2:11][O:12][CH2:13][CH2:14][CH2:15][N:16]3[CH2:20][CH2:19][CH:18]([NH:21]C(=O)[O-])[CH2:17]3)=[CH:9][C:4]=2[CH:3]=[CH:2]1.Cl.O.[OH-].[Na+]>C(OCC)(=O)C>[S:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][CH2:11][O:12][CH2:13][CH2:14][CH2:15][N:16]3[CH2:20][CH2:19][CH:18]([NH2:21])[CH2:17]3)=[CH:9][C:4]=2[CH:3]=[CH:2]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 865973431-{3-[2-(1-Benzothiophen-5-yl)ethoxy]propyl}-3-pyrrolidinylcarbamate

Product 1

HCID 219900601-{3-[2-(1-Benzothiophen-5-yl)ethoxy]propyl}-3-pyrrolidinamine

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

In 7.0 mL of ethyl acetate was dissolved 1.12 g of tert-butyl=1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-pyrrolidinylcarbamate, and 1.86 mL of 6 mol/L hydrochloric acid was added to the solution, after which the resulting mixture was heated under reflux for 1 hour. After the reaction mixture was cooled, water and ethyl acetate were added thereto and the pH was adjusted to 10 with a 2 mol/L aqueous sodium hydroxide solution, and the organic layer was separated. The organic layer was washed with water and then a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then distilled under reduced pressure to remove the solvent. The residue was purified by a column chromatography (eluent; chloroform:methanol=30:1 to 20:1) to obtain 0.38 g of 1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-pyrrolidinamine as a light-yellow oil.

Workup

  1. additionwas added to the solution
  2. temperatureafter which the resulting mixture was heated
  3. temperatureunder reflux for 1 hour
  4. temperatureAfter the reaction mixture was cooled
  5. customthe organic layer was separated
  6. washThe organic layer was washed with water
  7. dry with materiala saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate
  8. distillationdistilled under reduced pressure
  9. customto remove the solvent
  10. customThe residue was purified by a column chromatography (eluent; chloroform:methanol=30:1 to 20:1)

Sources & evidence

ORD record
ord-3ed3b1ea7a614475b0419ef504b3d359
Source dataset
uspto-grants-2006_08
Patent number
US07087594B2

Reaction notes

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