참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | HCID 178432276 | HCID 178432276 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | HCID 178432279 | HCID 178432279 | 80% |
반응 단계
Concentrated hydrochloric acid (0.7 ml) was added to a mixture of the crude N-benzhydrylidene-N′-(7-fluoro-2-methyl-1H-benzimidazol-5-yl)-hydrazine (325 mg) and ethanol (0.7 ml). This was stirred at 59 to 64° C. for one hour, and the reaction mixture was cooled to room temperature. Then, the precipitated solid was collected by filtration and dried. Thus, 7-fluoro-2-methyl-1H-benzimidazol-5-yl-hydrazine dihydrochloride (90 mg, 80%) was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08829199B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-3e6298c77679466680a8fed572bdbf52 |
|---|
| 출처 메모 | uspto-grants-2014_09 |
|---|
