Hydrochloric Acid → HCID 57480419, compound

Participants

Reaction Conditions

Reaction Steps

3.09 g of 5(S)-tert-butoxycarbonylamino-4(S)-hydroxy-2(S),7(S)-diisopropyl-8-[4-methoxy-3-(3-methoxypropyloxy)-phenyl]-octanoic acid N-(2-morpholinoethyl)amide are dissolved in 40 ml of 4N hydrochloric acid in dioxane at 0° C. and the solution is stirred at 0° C. for 2 hours. The reaction mixture is lyophilised and the title compound is obtained: Rf (dichloromethane/methanol=8:2)=0.27; HPLC Rt =9.52 minutes; HR FAB-MS (M+H)+ =566.

Provenance & Evidence