Dimethylamine → HCID 53639814, compound

HRID 744846Notes

Reaction equation

HRID 744846 reaction equation
C([O:3][C:4](=O)[CH2:5][C@@H:6]([NH:10][C:11]([O:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:12])[CH:7]([CH3:9])[CH3:8])C.[CH3:22][NH:23][CH3:24]>>[CH3:22][N:23]([CH3:24])[C:4](=[O:3])[CH2:5][C@@H:6]([NH:10][C:11]([O:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:12])[CH:7]([CH3:9])[CH3:8]

Participants

3

Reactant 2

HCID 674DimethylamineHCID 54226119HCID 54226119, compound

Product 1

HCID 53639814HCID 53639814, compound

Procedure

2.23 g of 3(R)-benzyloxycarbonylamino-4-methylpentanoic acid ethyl ester and 50 ml of 30% dimethylamine (in methanol) are stirred for 6 days at 75° C. in a bomb tube. The reaction mixture is concentrated by evaporation and the residue is purified by FC (dichloromethane/methanol=97:3). The title compound is obtained: Rf (dichloromethane/methanol=95:5)=0.40.

Workup

  1. concentrationThe reaction mixture is concentrated by evaporation
  2. customthe residue is purified by FC (dichloromethane/methanol=97:3)

Sources & evidence

ORD record
ord-2996299c24cd46338c6dbcfb8dc0ea81
Source dataset
uspto-grants-1996_09
Patent number
US05559111

Reaction notes

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