Trifluoroacetic acid → HCID 69943705, compound

Participants

Reaction Steps

A 1.32 g of 1-(p-methoxybenzyloxycarbonyl)-4-((2S)-4-(p-nitrobenzyloxycarbonyl) amino-2-hydroxybutyryl)piperazine was added to a mixture of 15 ml of trifluoroacetic acid and 1.35 ml of anisole, followed by 1 hour of reaction at room temperature. After removing trifluoroacetic acid by evaporation under a reduced pressure, a residue was adjusted to basic with sodium hydroxide and extracted with chloroform, and the organic layer was washed with water and dried over sodium sulfate, followed by evaporation of the solvent under a reduced pressure. Thereafter, the resulting residue was subjected to a silica gel column chromatography to yield 0.91 g of 1-((2S)-4-(p-nitrobenzyloxycarbonyl)amino-2-hydroxybutyryl)piperazine as a syrup.

Provenance & Evidence