Methyl Isocyanate → HCID 23369935, compound

HRID 744927Notes

Reaction equation

HRID 744927 reaction equation
[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][CH:14]([NH:17][CH2:18][CH3:19])[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:20][N:21]=[C:22]=[O:23]>C(Cl)(Cl)Cl>[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][CH:14]([N:17]([CH2:18][CH3:19])[C:22]([NH:21][CH3:20])=[O:23])[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 23369962Benzyl 4-(ethylamino)piperidine-1-carboxylate

Product 1

HCID 23369935HCID 23369935, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A solution of 1-benzyloxycarbonyl-4-(N-ethylamino)-piperidine (4.0 g) and methyl isocyanate (11 mL) was stirred for 30 hours at ambient temperature. The reaction mixture was diluted with chloroform and evaporated to give the urea as an oil; MS: m/z=320(M+1). The material was used without further purification.

Workup

  1. customevaporated

Sources & evidence

ORD record
ord-820c82f939614df6b8b64696d7cc7da1
Source dataset
uspto-grants-1996_09
Patent number
US05559132

Reaction notes

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